Amongst many functional biomarkers, one important biomarker is secretory IgA.
Secretory IgA is the predominant antibody or immune protein the body creates and releases in external secretions such as saliva, tears, and milk. It is also transported through the epithelial cells that line the intestines.
Secretory IgA represents the first line of defense of the gut lining and is central to the normal function of the GI tract as an immune barrier. sIgA plays an important role in controlling intestinal balance which is constantly presented with potentially harmful antigens such as pathogenic bacteria, parasites, yeast, viruses, abnormal cell antigens, and allergenic proteins (gluten, casein etc) .
Elevated levels of fecal secretory IgA have been associated with an upregulated immune response.
Low levels of this antibody can be caused by long term food protein allergen exposure, chronic stress, chronic infection from bacteria, viral, parasitic overgrowth.
Abnormal levels can be associated with:
Excess gas/wind/constioation and/or diarrhoea
Autoimmune diseases- Hashimoto’s, coeliac, rheumatoid, Parkinson’s l, lupus etc
Increased risk of food sensitivities
Inflammatory bowel disease- Crohns, colitis
Chronic mental stress
Poor digestive function
Altering dietary intake to address food sensitivities without knowing what your SIgA levels are can be a useless process as low levels not addressed will not address the immune issue to begin with.
For more information regarding SIgA and our GI Map stool analysis contact Lisa our clinic Manager